8f8u | pdb_00008f8u

Bifunctional ligase/repressor BirA from Klebsiella pneumoniae (Domain Swapped Dimer)

spinqualitylabelsall models 8f8u, resolution 2.85Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8f8u is a 2 chain structure with sequence from Klebsiella pneumoniae subsp. pneumoniae 1158. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.85Å Ligands: IMD Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A0W7ZMT5_KLEPN Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.[HAMAP-Rule:MF_00978]

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