8ppx | pdb_00008ppx

Influenza A/California/07/2009(H1N1) endonuclease in complex with flavonoid-like compound

spinqualitylabelsall models 8ppx, resolution 2.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8ppx is a 1 chain structure with sequence from Influenza A virus (A/California/07/2009(H1N1)). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.5Å Ligands: 85W, CL, MG, MN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function C3W5X6_9INFA Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.[HAMAP-Rule:MF_04063]

Proteopedia Page Contributors and Editors (what is this?)

OCA