| Structural highlights
Function
PSR2_PHYSO Secreted effector that possesses RNA silencing suppression activity by inhibiting the biogenesis of small RNAs in the host plant to promote enhanced susceptibility of host to the pathogen during infection (PubMed:23377181, PubMed:25387135, PubMed:30595554). Interferes with secondary siRNA production by associating with host dsRNA-binding protein DRB4 (PubMed:30595554). Inhibits the host salicylic acid pathway during infection (PubMed:25387135).[1] [2] [3]
References
- ↑ Qiao Y, Liu L, Xiong Q, Flores C, Wong J, Shi J, Wang X, Liu X, Xiang Q, Jiang S, Zhang F, Wang Y, Judelson HS, Chen X, Ma W. Oomycete pathogens encode RNA silencing suppressors. Nat Genet. 2013 Mar;45(3):330-3. PMID:23377181 doi:10.1038/ng.2525
- ↑ Xiong Q, Ye W, Choi D, Wong J, Qiao Y, Tao K, Wang Y, Ma W. Phytophthora suppressor of RNA silencing 2 is a conserved RxLR effector that promotes infection in soybean and Arabidopsis thaliana. Mol Plant Microbe Interact. 2014 Dec;27(12):1379-89. PMID:25387135 doi:10.1094/MPMI-06-14-0190-R
- ↑ Hou Y, Zhai Y, Feng L, Karimi HZ, Rutter BD, Zeng L, Choi DS, Zhang B, Gu W, Chen X, Ye W, Innes RW, Zhai J, Ma W. A Phytophthora Effector Suppresses Trans-Kingdom RNAi to Promote Disease Susceptibility. Cell Host Microbe. 2019 Jan 9;25(1):153-165.e5. PMID:30595554 doi:10.1016/j.chom.2018.11.007
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