Adenosine A2A receptor

spinqualitylabelsall models Human A2AR (mutant) complex with adenosine 2ydo Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Adenosine A2A receptor (A2AR) is one of the G protein-coupled receptors. The protein uses adenosine as the preferred endogenous agonist and is involved in increasing intracellular cAMP levels. Disease A2AR antagonists are being tested in the treatment of Alzheimer's Disease. Relevance A2AR is responsible for regulating myocardial blood flow. It is involved in cerebral and renal blood flow, immune function, pain regulation and sleep. For details see G protein-coupled receptor. A2AR is blocked by caffeine producing the arousal effect. For details see Caffeine. See also: G protein-coupled receptor Receptor Transmembrane (cell surface) receptors Structural highlights Like other G proteins, A2AR has 7 transmembrane helices. A2AR has a ligand-binding cavity. Adenosine binding site. 3D Structures of adenosine A2A receptor Adenosine A2A receptor 3D structures

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