DNA adenine methylase

spinqualitylabelsall models Phage T4 DNA adenine metylase complex with SAH, DNA and I- ion (purple) (PDB code 1q0t) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function DNA adenine methylase (DAM) adds a methyl group to adenines in the DNA sequence GATC. The daughter strand remains unmethylated for a short while during which mismatch repair of DNA can take place. DAM has a role in regulation of replication by delaying the availability of the origin of replication to activation during the cell cycle. The origin of replication in E. coli contains 11 GATC sequences. In E. coli, downstream GATC sequences are methylated to promote RNA transcription. Structural highlights DAM uses S-adenosyl-L-homocysteine (AdoHcy, SAH) as methyl donor. Phage T4 DNA adenine metylase with SAH, DNA and I- ions SAH binding site DNA binding site Iod coordination site (PDB code 1q0t)

3D Structures of DNA adenine methylase

Updated on 25-February-2019

1q0t – T4DAM + SAH – Enterobacter phage T4
1q0t, 1yf3, 1yfj – T4DAM + SAH + DNA
1yfl – T4DAM + sinefungin + DNA
2g1p, 4rtk, 4rtn, 4rtq – EcDAM + SAH + DNA – Escherichia coli
2ore, 4gbe – EcDAM + SAH
4gol, 4gom, 4gon, 4goo – EcDAM + Aza-SAM derivative
4rtj, 4rtl, 4rto – EcDAM + sinefungin + DNA
4rtm, 4rtp, 4rtr, 4rts – EcDAM + AdoMet + DNA

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