Galectin

spinqualitylabelsall models Structure of human galectin-1 complex with lactose, mercaptoethanol and sulfate (PDB entry 1w6o) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Galectin or galactoside-binding soluble lectin (GAL) are lectins which bind β-galactosidase (BGAL). GAL contains a carbohydrate recognition domain (CRD) residues 113-250. GAL-1 is thought to play a role as autocrine negative growth factor that regulates cell proliferation. GAL-2 is expressed primarily in gastrointestinal tract. GAL-3 has broad biological functionality. GAL-4 has 2 CRDs. GAL-5 is found in rat is a β-galactoside binding lectin. GAL-7 is associated with epithelial cells. GAL-8 has a role in cellular defense against bacterial infection and vacuolar damage. GAL-9 affects eosinophil survival. GAL-10 or Charcot-Leyden crystal protein acts on biological membranes to regulate the multifunctional lysophospholipids. GAL-13 is a placental protein which does not bind β-galactosides. Relevance GAL are known to inhibit chronic inflammation. GAL-3 has a role in experimental autoimmune encephalomyelitis and melanoma methastasis. Structural highlights The CRD is a β-sandwich long enough to bind a tetrasaccharide. A lactose ligand is bound at the concave face of the β-sheet. Water molecules shown as red spheres. 3D structures of galectin Galectin 3D structures

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