Linear gramicidin synthase

spinqualitylabelsall models Linear gramicidin synthease subunit A initiation module complex with sulfate (PDB code 5es5). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Linear gramicidin synthase LgrA is a biosynthetic enzyme which synthesizes natural products for therapeutics using a modular synthetic logic where each module adds one amino acid to the growing chain. Thus, LgrA is a non-ribosomal peptide synthetase. Linear gramicidin is a 15 amino acid long polypeptide which is synthetized by synthases LgrA, LgrB, LgrC, LgrD which comprise 16 modules. Structural highlights LgrA core contains 3 essential domains. Adenylation domain which activates the specific amino acid by adenylation, the thiolation domain which produces a thiol ester and the condensation domain which catalyzes the elongation of the peptide chain.

Updated on 05-October-2020

3D structures of linear gramicidin synthase subunit A

5jnf, 5es6 - BpLgrA 2 domains 2-584 - Brevibacillus parabrevis
6ulz - BpLgrA adenylation domain (mutant) 2-684
5es7 - BpLgrA adenylation domain 2-684 + Val + APC + FON
5es5, 5es8, 5es9 - BpLgrA initiation domain 2-766
6mfw - BpLgrA 4 domains 2-1198
6mfx - BpLgrA 4 domains (mutant) 2-1198
6mfy, 6mg0 - BpLgrA 5 domains 2-1716
6mfz - BpLgrA 2-1802

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