Mandelate dehydrogenase

spinqualitylabelsall models Structure of S-mandelate dehydrogenase tetramer complex with 3-indolelactate and flavin mononucleotide (PDB entry 2a7p) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function S-mandelate dehydrogenase (SMD) catalyzes the conversion of S-2-hydroxy-2-phenylacetate and acceptor to 2-oxo-2-phenylacetate and reduced acceptor. SMD is a FMN-dependent enzyme. D-mandelate dehydrogenase (DMD) catalyzes the NAD-dependent oxidation of D-mandalate to phenylglyoxylate. Structural highlights The biological assembly of SMD from Pseudomonas putida is homotetramer. The poor substrate indolelactate binds in the active site of SMD. Water molecules shown as red spheres.

3D structures of mandelate dehydrogenase

Updated on 14-December-2025

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• S-mandelate dehydrogenase
  • 6bfg – PpSM + FMN - Pseudomonas putida
    
  • 1huv, 1p4c, 1p5b, 2a7n, 3giy – PpSM (mutant) + FMN
    
  • 2a7p – PpSMD (mutant) + FMN + 3-indolelacetate
    
  • 2a85 – PpSMD (mutant) + FMN + 2-hydroxyoctanoate
    
  • 8wl1 – LbSMD – Levilactobacillus brevis
    
  • 8wl3, 8wl4 – LbSMD (mutant)
    
• D-mandelate dehydrogenase
  • 2w2k – RgDMD – Rhodotorula graminis
    
  • 2w2l – RgDMD + NAD
    
  • 3wfi – EfDMD – Enterococcus faecium
    
  • 3wfj – EfDMD + NAD
    
  • 5x20 – EfDMD + NAD + aniline(oxo)acetate
    

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