Met repressor

spinqualitylabelsall models EcMR (mutant) complex with corepressor SAM, Ca+2 ion (green) and DNA 1mjo Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Met repressor (MR) interacts with the DNA operator (Met box) repressing methionine synthesis. The co-repressor of MR is S-adenosyl methionine (SAM) which is a product of methionine synthesis. Binding of SAM to MR increases the repressor affinity to the DNA thus halting methionine synthesis. For additional details see Taylor met repressor Joe Granger Methionine Repressor: Escherichia coli. Structural highlights EcMR (mutant) with corepressor SAM, Ca+2 ion and DNA. SAM binds to MR in a hydrophobic pocket between 2 monomers. Water molecules are shown as red spheres.

3D Structures of Met repressor

Updated on 10-July-2019

Taylor met repressor – EcMR – Escherichia coli
Joe Granger Methionine Repressor: Escherichia coli – EcMR (mutant)
1cma – EcMR + DNA
1mjm – EcMR (mutant) + DNA
1cmc – EcMR + SAM
1mjl, 1mjp – EcMR (mutant) + SAM
1mj2, 1mjo, 1mjq – EcMR (mutant) + SAM + DNA

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Michal Harel, Alexander Berchansky