Pyranose oxidase

spinqualitylabelsall models Pyranose oxidase complex with FAD and deoxy-fluoro-glucopyranose (PDB code 3k4l) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Pyranose oxidase or pyranose 2-oxidase (P2O) or C-glucosyl oxidoreductase catalyzes the conversion of D-glucose and molecular oxygen to 2-dehydro-D-glucose and H2O2. It is abundant in lignin-degrading white rot fungi. P2O is a tetramer flavoprotein containing the prosthetic group FAD in each monomer. P2O oxidizes several aldopyranoses with the preferred electron donors being D-glucose, D-xylose and D-sorbose. Relevance Converting common sugars and sugar derivatives with P2O provides a pool of sugar-derived intermediates for the synthesis of rare sugars, fine chemicals and drugs. Structural highlights The active site of P2O is gated by a highly conserved loop which determines the substrate specificity. Water molecules are shown as red spheres. The active site contains the FAD cofactor.

3D Structures of pyranose oxidase

Updated on 23-August-2026

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• Pyranose oxidase
  • 1tzl – PeP2O + FAD – Peniophora
    
  • 2f6c – PeP2O (mutant) + FAD
    
  • 3bg6, 3bg7, 3bly, 3fdy – TmP2O (mutant) + FAD – Trametes multicolor
    
  • 1tt0, 2igk – ToP2O + FAD – Trametes ochracea
    
  • 2igm, 2ign, 3k4b, 3k4c, 3k4j, 3k4k, 3k4n, 3lsh, 3lsi, 3lsk, 4mok – ToP2O (mutant) + FAD
    
  • 4mif, 4mig – ToP2O + FAD derivative
    
  • 3lsm – ToP2O (mutant) + FAD derivative
    
  • 9fl2 – P2O + FAD – Oscillatoria principes
    
  • 8qve – P2O + FAD – Deinococcus aerius
    
• Pyranose oxidase complex
  • 2f5v – PeP2O (mutant) + FAD + keto-glucose
    
  • 2igo, 3k4l, 3k4m, 4mih – ToP2O (mutant) + FAD + deoxy-fluoro-glucopyranose
    
  • 4moe, 4mof, 4mog, 4moh, 4moi, 4moj, 4mol – ToP2O (mutant) + FAD derivative + deoxy-fluoro-glucopyranose
    
  • 4mom, 4mop, 4moq, 4mor – ToP2O (mutant) + FAD derivative + deoxy-fluoro-galactopyranose
    
  • 4moo – ToP2O (mutant) + FAD derivative + deoxy-fluoro-galactose
    
  • 4mos – ToP2O (mutant) + FAD derivative + deoxy-fluoro-galactopyranose + deoxy-fluoro-galactose
    
  • 3pl8 – ToP2O (mutant) + FAD + deoxy-fluoro-glucose
    

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