RING box protein

spinqualitylabelsall models Human RING finger protein 1 (green) complex with cullin-1 (grey), glomulin (magenta) and Zn+2 ions (grey) (PDB code 4f52) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D RING box protein (RBX) makes a heterodimer with cullin. The heterodimer is essential for the protein ubiquitination process. RBX1 is a component of the SCF (Skp1-cullin-F box protein) E3 ubiquitin ligase complex. RBX contains a RING-type zinc finger domain. The RING domain is 40 to 60 residues long and binds two Zn atoms. It is involved in protein-protein interaction. Relevance Overexpression of RBX1 contributes to tumor progression and poor prognosis of non-muscle-invasive bladder transitional cell carcinoma. RBX1 and RBX2 are overexpressed in multiple human cancer tissues and required for the growth and survival of cancer cells.

3D Structures of RING box protein

Ring box protein 3D structures

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel