RNA Interference

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D load='3dlh' size='300' frame='false' scene='RNA_Interference/3dlh/2'
guide-strand-containing Argonaute protein silencing complex (3dlh), resolution 3.00Å (initial scene)
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

RNA Interference (RNAi) is a system in living cells that helps control the level of activity of genes. In RNAi, a long double stranded RNA is cleaved into shorter strands. One strand known as the guide strand is complimentary to the mRNA gene product of a gene of interest. This guide strand is incorporated into an RNA-induced silencing complex (RISC) and subsequently binds the mRNA of the gene of interest. After binding, the RNA/RISC complex subsequently silences the mRNA of interest via cleavage of the mRNA strand.

Schematic of RNAi Interference in Mammalian Cells

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D load='1rpu' size='300' frame='false' scene='User:Wayne_Decatur/Plant_Viral_Protein_p19_Suppression_of_RNA_Silencing/View1/2'
viral silencing suppressor bound to a siRNA (1rpu), resolution 2.50Å (initial scene)
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

Articles in Proteopedia concerning RNA Interference include:

• • Suppression of RNA Silencing by Viruses
  • Plant Viral Protein p19 Supression of RNA Silencing
  • Tomato aspermy virus protein 2b Suppression of RNA Silencing
  • Flock house virus B2 protein Suppression of RNA Silencing

See RNAi in action by viewing this RNAi Animation.

To view automatically seeded indices concerning RNA Interference, see:

• • Argonaute
  • Dicer
  • Drosha
  • Piwi
  • RISC
  • RNAi
  • RNAi Suppression
  • RNA Interference
  • Slicer

To view other Proteopedia pages about diseases & drug targets, see: Pharmaceutical Drug Targets

Proteopedia Page Contributors and Editors (what is this?)

David Canner, Wayne Decatur, Eric Martz