Selenocysteine lyase

spinqualitylabelsall models Rat selenocysteine lyase complex with PLP, cysteine, phosphate and glycerol (PDB code 3a9y) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Selenocysteine lyase (SCL), (CsbD) or cysteine desulferase catalyzes the breakdown of Selenocysteine to alanine and H2Se. SCL uses PLP as a coenzyme. Selenocysteine is a naturally occuring analog of cysteine in which the sulfur atom is substituted by selenium. This seleno-amino acid is a component of selenoproteins and is incorporated into them by a special tRNA with anticodon complimentary to UGA codon. Relevance Knockout SCL mice show effects on their hepatic glucose and lipid homeostasis. Structural highlights Rat SCL structure shows the PLP moiety and bound L-cysteine within the active site cavity. The cysteine carboxyl end forms salt bridge with SCL Arg and 2 hydrogen bonds with Ser and Asn while its amino group forms 2 hydrogen bonds with Ser and Ala. Water molecules are shown as red spheres. PLP interactions. Whole active site.

3D structures of selenocysteine lyase

Updated on 15-November-2023

Selenocysteine, 3gzd - hSCL + PLP derivative - human
3a9x - rSCL + PLP - rat
3a9z - rSCL + PLP + selenopropionate
3a9y - rSCL + PLP + cysteine
4q75 - AtSCL + PLP derivative + cysteine derivative - Arabidopsis thaliana
4q76 - AtSCL (mutant) + PLP derivative + cysteine derivative
1jf9, 1c0n, 6ndn, 6o10, 7rrn, 7ruj, 7rw3 - EcCsdB + PLP - Escherichia coli
6o12 - EcCsdB (mutant) + PLP
1kmj, 1kmk, 5db5, 6mr2, 6uy5 - EcCsdB + PLP + cysteine derivative
6mr6, 6mre, 6mrh, 6mri, 6o13 - EcCsdB (mutant) + PLP + cysteine derivative
6o11 - EcCsdB (mutant) + cysteine derivative
5ft4, 5ft5, 5ft6 - EcCsdA + PLP
1i29 - EcCsdB + PLP + propagylglycine
5ft8 - EcCsdA + CsdE + PLP
7tlm - ApSCL + PLP + Ala – Atopobium parvulum
7tlq, 7tlr - ApSCL (mutant) + PLP

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