Selenocysteine synthase

spinqualitylabelsall models Human selenocysteine synthase containing phosphoserine complex with tRNASec, monothiophosphate, deoxypyridoxine phosphate (PDB entry 3hl2) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Selenocysteine synthase or O-phosphoseryl-tRNA(Sec) selenium transfrase (SecS) converts phospho-seryl-tRNA (tRNASec) into selenocysteinyl-tRNA using selenophosphate as the Se donor. Disease Mutations in SecS cause cerebello-cerebral atrophy. Structural insights The active site of SecS contains the PLR phosphate donor, serinophosphate 2002, serinophosphate 2001 and tRNASec CCA terminal . Water molecules are shown as red spheres.

3D Structures of selenocysteine synthase

Updated on 15-March-2022

4zdl – hSecS (mutant) - human
3hl2 - hSecS + tRNASec
4zdo, 4zdp – hSecS (mutant) + tRNASec
7l1t – hSecS + pyridoxine derivative
3bc8, 3bca - mSecS elastase-resistant fragment - mouse

3bcb - mSecS elastase-resistant fragment + phosphate

2z67 - SecS - Methanococcus maripaludis

3w1i – AaSecS + pyridine derivative – Aquifex aeolicus
3wcn – AaSecS (mutant)
3w1h, 3wco – AaSecS (mutant) + pyridine derivative
3w1j – AaSecS + pyridine derivative
3w1k – AaSecS (mutant) + pyridine derivative + tRNASec

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Michal Harel, Alexander Berchansky