Tetherin

spinqualitylabelsall models Glycosylated human tetherin ectodomain dimer 2xg7 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Tetherin is a membrane-associated protein that may prevent the release of enveloped viruses from their host cells Tetherin or bone marrow stromal antigen 2 (BST-2) has been shown to prevent the release of HIV-1 virions and may be an effective inhibitor of other enveloped viruses as well such as Lassa and Marburg viruses. Tetherin inhibits the release of virions by binding to viral particles budding from the cell membrane, preventing the release of these infectious particles. The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells. The tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine. While tetherin may be an effective inhibitor of some viruses, other viruses have been shown to produce viral proteins that downregulate the production and expression of some cellular proteins, including tetherin. Some strains of HIV-1 as well as Ebola viral particles produce viral proteins shown to downregulate tetherin expression on the surface of the cell membrane. Additional Resources Human Immunodeficiency Virus Viral Infections

3D structures of tetherin

Updated on 23-November-2020

Human Immunodeficiency Virus, Viral Infections, 2xg7, 3mqb, 3mqc – hBST-2 ectodomain – human
3mq7, 3mq9 - hBST-2 ectodomain (mutant)
2lk9 – hBST-2 transmembrane (mutant) – NMR
4p6z – hBST-2 in adaptor protein complex
6cm9, 6owt, 6cri, 6d83, 6d84, 6dff – hBST-2/Nef in adaptor protein complex – Cryo EM
3ni0 - BST-2 ectodomain – mouse

References

Sakuma, Noda, Urata, Kawaoka, & Yasuda (2009). Inhibition of Lassa and Marburg Virus Production by Tetherin. Journal of Virology. 83:2382-2385.

Neil, Zang, & Beiniasz (2008). Tetherin inhibits retroviral release and is antagonized by HIV-1 Vpu. Nature. 451: 425-430.

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