Thiaminase

spinqualitylabelsall models Thiaminase II complex with pyrimidine derivative 1yak Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Thiaminase (Thi) or thiamine pyridinylase cleaves vitamin B1. Thiaminase I catalyzes the elimination of the thiazole ring moiety from the thiamin through substitution of the methylene group with a nitrogenous base or sulfhydryl compound. Thiaminase II catalyzes the hydrolysis of thiamin . Structural highlights The active site of thiaminase II contains a pyrimidine derivative. Three residues participate in the substrate binding and the pyrimidine ring is sandwiched between two tyrosine residues.

3D Structures of thiaminase

Updated on 25-November-2020

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• Thiaminase I
  • 4hcw – amThia I – amoeba
    
  • 4hcy – amThia I + deazathiamin
    
  • 2thi, 3thi – BtThia I – Bacillus thiaminolyticus
    
  • 4thi – BtThia I + pyrimidine derivative
    
  • 4kys – Thia I (mutant) + thiamin – Clostridium botulinum
    
• Thiaminase II
  • 4fn6 – Thia II – Staphylococcus aureus
    
  • 3no6 – Thia II – Staphylococcus epidermidis
    
  • 1yaf – BsThia II – Bacillus subtilis
    
  • 1yak – BsThia II + pyrimidine derivative
    
  • 2qcx – BsThia II (mutant) + pyrimidine derivative
    

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