3k45 | pdb_00003k45

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Template:STRUCTURE 3k45

File:3k45.jpg

Alternate Binding Modes Observed for the E- and Z-isomers of 2,4-Diaminofuro[2,3d]pyrimidines as Ternary Complexes with NADPH and Mouse Dihydrofolate Reductase

Template:ABSTRACT PUBMED 19748785

About this Structure

3K45 is a 1 chain structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  1. Gangjee A, Li W, Lin L, Zeng Y, Ihnat M, Warnke LA, Green DW, Cody V, Pace J, Queener SF. Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors. Bioorg Med Chem. 2009 Oct 15;17(20):7324-36. Epub 2009 Aug 22. PMID:19748785 doi:10.1016/j.bmc.2009.08.044

Page seeded by OCA on Wed Oct 14 10:20:11 2009

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