1p9x | pdb_00001p9x

THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC

File:1p9x.gif

spinqualitylabelsall models 1p9x, resolution 3.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

Overview

The crystal structure of the ketolide telithromycin bound to the, Deinococcus radiodurans large ribosomal subunit shows that telithromycin, blocks the ribosomal exit tunnel and interacts with domains II and V of, the 23S RNA. Comparisons to other clinically relevant macrolides provided, structural insights into its enhanced activity against macrolide-resistant, strains.

About this Structure

1P9X is a Single protein structure of sequence from Deinococcus radiodurans with TEL as ligand. Full crystallographic information is available from OCA.

Reference

Structural insight into the antibiotic action of telithromycin against resistant mutants., Berisio R, Harms J, Schluenzen F, Zarivach R, Hansen HA, Fucini P, Yonath A, J Bacteriol. 2003 Jul;185(14):4276-9. PMID:12837804

Page seeded by OCA on Sun Nov 25 02:14:48 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA