3ig6 | pdb_00003ig6
From Proteopedia
Low molecular weigth human Urokinase type Plasminogen activator 2-[6-(3'-Aminomethyl-biphenyl-3-yloxy)-4-(3-dimethylamino-pyrrolidin-1-yl)-3,5-difluoro-pyridin-2-yloxy]-4-dimethylamino-benzoic acid complex
Disease
Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[191840]
About this Structure
3IG6 is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- West CW, Adler M, Arnaiz D, Chen D, Chu K, Gualtieri G, Ho E, Huwe C, Light D, Phillips G, Pulk R, Sukovich D, Whitlow M, Yuan S, Bryant J. Identification of orally bioavailable, non-amidine inhibitors of Urokinase Plasminogen Activator (uPA). Bioorg Med Chem Lett. 2009 Oct 1;19(19):5712-5. Epub 2009 Aug 7. PMID:19703768 doi:10.1016/j.bmcl.2009.08.008
Page seeded by OCA on Wed Oct 14 10:23:34 2009
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- U-plasminogen activator
- Adler, M.
- Whitlow, M.
- Blood coagulation
- Disulfide bond
- Egf-like domain
- Fibrinolysis
- Glycoprotein
- Hydrolase
- Kringle
- Pharmaceutical
- Phosphoprotein
- Plasminogen activation
- Polymorphism
- Protease
- S1 site inhibitor
- Secreted
- Selective
- Serine protease
- Structure-based drug design
- Urokinase
- Zymogen
