3hhm | pdb_00003hhm
From Proteopedia
Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin
Template:ABSTRACT PUBMED 19805105
Disease
Known disease associated with this structure: Breast cancer, somatic OMIM:[171834], Colorectal cancer, somatic OMIM:[171834], Gastric cancer, somatic OMIM:[171834], Hepatocellular carcinoma, somatic OMIM:[171834], Keratosis, seborrheic, somatic OMIM:[171834], Nevus, epidermal OMIM:[171834], Nonsmall cell lung cancer, somatic OMIM:[171834], Ovarian cancer, somatic OMIM:[171834]
About this Structure
3HHM is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Mandelker D, Gabelli SB, Schmidt-Kittler O, Zhu J, Cheong I, Huang CH, Kinzler KW, Vogelstein B, Amzel LM. A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane. Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):16996-7001. Epub 2009 Sep 23. PMID:19805105
Page seeded by OCA on Wed Oct 21 09:50:12 2009
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Phosphatidylinositol-4,5-bisphosphate 3-kinase
- Amzel, L M.
- Gabelli, S B.
- Mandelker, D.
- Vogelstein, B.
- 5-triphosphate
- Atp-binding
- Disease mutation
- H1047r
- Kinase
- Nucleotide-binding
- Oncogene
- P110
- P85
- Phosphatidilynositol 3
- Pi3k
- Pi3kca
- Pik3r1
- Polymorphism
- Transferase
- Transferase/oncoprotein complex
- Wortmannin
