1d65 | pdb_00001d65
MOLECULAR STRUCTURE OF THE B-DNA DODECAMER D(CGCAAATTTGCG)2; AN EXAMINATION OF PROPELLER TWIST AND MINOR-GROOVE WATER STRUCTURE AT 2.2 ANGSTROMS RESOLUTION
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Overview
The crystal structure of the dodecanucleotide duplex d(CGCAAATTTGCG)2 has, been solved to 2.2 A resolution and refined to an R-factor of 18.1% with, the inclusion of 71 water molecules. The structure shows propeller twists, of up to -20 degrees for the A.T base-pairs, although there is probably, only one (weak) three-centre hydrogen bond in the six base-pair AT narrow, minor-groove region. An extensive ribbon of hydration has been located in, this groove that has features distinctive from the classic "spine of, hydration". Solvation around phosphate groups is described, with several, instances of water molecules bridging between phosphates.
About this Structure
1D65 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Molecular structure of the B-DNA dodecamer d(CGCAAATTTGCG)2. An examination of propeller twist and minor-groove water structure at 2.2 A resolution., Edwards KJ, Brown DG, Spink N, Skelly JV, Neidle S, J Mol Biol. 1992 Aug 20;226(4):1161-73. PMID:1518049
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