Sandbox 1b41

Human Acetylcholinesterase (1b41)

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1b41, resolution 2.76Å (default scene)
Ligands:	NDG, FUC, NAG
Gene:	ACHE (Homo sapiens)
Activity:	Acetylcholinesterase, with EC number 3.1.1.7
Structural annotation: Resources: CATH : 1B41A00, 1B41B00 InterPro : Ipr002018, Ipr019819, Ipr000997, Ipr019826, Ipr014788, Ipr018354, Ipr003571 Pfam : PF00135, PF00087 SCOP : d1b41a_, d1b41b_
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

The human acetylcholinesterase (AChE) is an enzyme which hydrolyses the neurotransmitter Acethylcholin (ACh) in the neuromuscular junctions and in other cholinergic synapses to terminate the neuronal signal. In the physiological conditions, AChE exists as tetramers associated with either collagen-like Q subunit (ColQ) or proline-rich membrane-anchoring protein (PRiMA). There is also a monomeric form which is soluble in the blood.