1y0h | pdb_00001y0h

Structure of Rv0793 from Mycobacterium tuberculosis

File:1y0h.gif

spinqualitylabelsall models 1y0h, resolution 1.600Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

Overview

Mycobacterium tuberculosis infects millions worldwide. The Structural, Genomics Consortium for M. tuberculosis has targeted all genes from this, bacterium in hopes of discovering and developing new therapeutic agents., Open reading frame Rv0793 from M. tuberculosis was annotated with an, unknown function. The 3-dimensional structure of Rv0793 has been solved to, 1.6 A resolution. Its structure is very similar to that of Streptomyces, coelicolor ActVA-Orf6, a monooxygenase that participates in tailoring of, polyketide antibiotics in the absence of a cofactor. It is also similar to, the recently solved structure of YgiN, a quinol monooxygenase from, Escherichia coli. In addition, the structure of Rv0793 is similar to, several structures of other proteins with unknown function. These latter, structures have been determined recently as a result of structural genomic, projects for various bacterial species. In M. tuberculosis, Rv0793 and its, homologs may represent a class of monooygenases acting as reactive oxygen, species scavengers that are essential for evading host defenses. Since the, most prevalent mode of attack by the host defense on M. tuberculosis is by, reactive oxygen species and reactive nitrogen species, Rv0793 may provide, a novel target to combat infection by M. tuberculosis.

About this Structure

1Y0H is a Single protein structure of sequence from Mycobacterium tuberculosis with ACT as ligand. Full crystallographic information is available from OCA.

Reference

The crystal structure of Rv0793, a hypothetical monooxygenase from M. tuberculosis., Lemieux MJ, Ference C, Cherney MM, Wang M, Garen C, James MN, J Struct Funct Genomics. 2005 Dec;6(4):245-57. Epub 2006 Feb 22. PMID:16496224

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