3hxq | pdb_00003hxq
From Proteopedia
Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding
About this Structure
3HXQ is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Gilbert JC, DeFeo-Fraulini T, Hutabarat RM, Horvath CJ, Merlino PG, Marsh HN, Healy JM, Boufakhreddine S, Holohan TV, Schaub RG. First-in-human evaluation of anti von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteers. Circulation. 2007 Dec 4;116(23):2678-86. Epub 2007 Nov 19. PMID:18025536 doi:10.1161/CIRCULATIONAHA.107.724864
- Diener JL, Daniel Lagasse HA, Duerschmied D, Merhi Y, Tanguay JF, Hutabarat R, Gilbert J, Wagner DD, Schaub R. Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779. J Thromb Haemost. 2009 Jul;7(7):1155-62. Epub 2009 Apr 24. PMID:19422452 doi:10.1111/j.1538-7836.2009.03459.x
Page seeded by OCA on Wed Nov 18 20:08:26 2009
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Diener, J L.
- Fremont, D H.
- Huang, R H.
- Sadler, J E.
- Schaub, R G.
- Aptamer
- Arc1772
- Arc1779
- Blood clotting/blood clotting regulator complex
- Blood coagulation
- Cell adhesion
- Cleavage on pair of basic residue
- Disease mutation
- Disulfide bond
- Extracellular matrix
- Glycoprotein
- Hemostasis
- Isopeptide bond
- Platelet glycoprotein ib
- Polymorphism
- Secreted
- Ubl conjugation
- Von willebrand disease
- Vwf
