3i5n | pdb_00003i5n
From Proteopedia
Crystal structure of c-Met with triazolopyridazine inhibitor 13
Disease
Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[164860], Renal cell carcinoma, papillary, familial and sporadic OMIM:[164860], Autism, suseptibility to, 9 OMIM:[164860]
About this Structure
3I5N is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Boezio AA, Berry L, Albrecht BK, Bauer D, Bellon SF, Bode C, Chen A, Choquette D, Dussault I, Fang M, Hirai S, Kaplan-Lefko P, Larrow JF, Lin MH, Lohman J, Potashman MH, Qu Y, Rex K, Santostefano M, Shah K, Shimanovich R, Springer SK, Teffera Y, Yang Y, Zhang Y, Harmange JC. Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6307-12. Epub 2009 Sep 27. PMID:19819693 doi:10.1016/j.bmcl.2009.09.096
Page seeded by OCA on Wed Jan 13 13:54:31 2010
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Receptor protein-tyrosine kinase
- Bellon, S F.
- Boezio, A A.
- Long, A M.
- Whittington, D A.
- Alternative splicing
- Atp-binding
- Chromosomal rearrangement
- Disease mutation
- Disulfide bond
- Glycoprotein
- Hgf/sf
- Kinase
- Membrane
- Nucleotide-binding
- Phosphoprotein
- Polymorphism
- Proto-oncogene
- Receptor
- Receptor tyrosine kinase
- Rtk
- Scatter factor receptor
- Transferase
- Transmembrane
- Tyrosine-protein kinase
