1a52 | pdb_00001a52

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File:1a52.png

Template:STRUCTURE 1a52

ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN COMPLEXED TO ESTRADIOL

Template:ABSTRACT PUBMED 9600906

Disease

Known disease associated with this structure: Breast cancer OMIM:[133430], Estrogen resistance OMIM:[133430], Atherosclerosis, susceptibility to OMIM:[133430], HDL response to hormone replacement, augmented OMIM:[133430], Migraine, susceptibility to OMIM:[133430], Myocardial infarction, susceptibility to OMIM:[133430]

About this Structure

1A52 is a 2 chains structure with sequences from Homo sapiens. The September 2003 RCSB PDB Molecule of the Month feature on Estrogen Receptor by David S. Goodsell is 10.2210/rcsb_pdb/mom_2003_9. Full crystallographic information is available from OCA.

Reference

  1. Tanenbaum DM, Wang Y, Williams SP, Sigler PB. Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains. Proc Natl Acad Sci U S A. 1998 May 26;95(11):5998-6003. PMID:9600906

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