2zvt | pdb_00002zvt
From Proteopedia
Cys285Ser mutant PPARgamma ligand-binding domain complexed with 15-deoxy-delta12,14-prostaglandin J2
Disease
Known disease associated with this structure: Carotid intimal medial thickness 1 OMIM:[601487], Insulin resistance, severe, digenic OMIM:[601487], Lipodystrophy, familial partial, type 3 OMIM:[601487], Obesity, severe OMIM:[601487], Obesity, resistance to OMIM:[601487], Diabetes, type 2 OMIM:[601487], Glioblastoma, susceptibility to OMIM:[601487]
About this Structure
2ZVT is a 2 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Waku T, Shiraki T, Oyama T, Morikawa K. Atomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligands. FEBS Lett. 2009 Jan 22;583(2):320-4. Epub 2008 Dec 26. PMID:19101554 doi:10.1016/j.febslet.2008.12.017
Page seeded by OCA on Thu Jan 28 14:23:20 2010
