3kga | pdb_00003kga
From Proteopedia
Crystal structure of MAPKAP kinase 2 (MK2) complexed with a potent 3-aminopyrazole ATP site inhibitor
About this Structure
3KGA is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Velcicky J, Feifel R, Hawtin S, Heng R, Huppertz C, Koch G, Kroemer M, Moebitz H, Revesz L, Scheufler C, Schlapbach A. Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1293-7. Epub 2009 Nov 3. PMID:20060294 doi:10.1016/j.bmcl.2009.10.138
Page seeded by OCA on Wed Feb 17 09:55:56 2010
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Non-specific serine/threonine protein kinase
- Be, C.
- Huppertz, C.
- Izaac, A.
- Kroemer, M.
- Pflieger, D.
- Scheufler, C.
- Schlapbach, A.
- Velcicky, J.
- 3-aminopyrazole scaffold
- Activation loop deletion
- Alternative splicing
- Atp-binding
- Atp-site kinase inhibitor
- Induced fit
- Kinase
- Novel hydrophobic pocket
- Nucleotide-binding
- Phosphoprotein
- Polymorphism
- Scaffold hoping
- Serine/threonine-protein kinase
- Small molecule inhibitor
- Transferase
