3kck | pdb_00003kck
From Proteopedia
A Novel Chemotype of Kinase Inhibitors
Disease
Known disease associated with this structure: Leukemia, acute myelogenous OMIM:[147796], Myelofibrosis, idiopathic OMIM:[147796], Myeloproliferative disorder with erythrocytosis OMIM:[147796], Polycythemia vera OMIM:[147796], Thrombocythemia, essential OMIM:[147796], Budd-Chiari syndrome OMIM:[147796]
About this Structure
3KCK is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Wang T, Ledeboer MW, Duffy JP, Salituro FG, Pierce AC, Zuccola HJ, Block E, Shlyakter D, Hogan JK, Bennani YL. A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors. Bioorg Med Chem Lett. 2010 Jan 1;20(1):153-6. Epub 2009 Nov 12. PMID:19945871 doi:10.1016/j.bmcl.2009.11.021
Page seeded by OCA on Wed Feb 17 09:58:31 2010
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Non-specific protein-tyrosine kinase
- Ledeboer, M W.
- Wang, T.
- Zuccola, H J.
- Atp-binding
- Chromosomal rearrangement
- Disease mutation
- Inhibitor
- Jak2
- Janus kinase
- Kinase
- Membrane
- Nucleotide-binding
- Phosphoprotein
- Polymorphism
- Proto-oncogene
- Sh2 domain
- Transferase
- Tyrosine-protein kinase
