Acetylcholine
From Proteopedia
Acetylcholine at the Wikipedia

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Acetylcholinesterase hydrolysizes the neurotransmitter acetylcholine (ACh), producing choline and an acetate group. ACh directly binds Ser200 (via its nucleophilic Oγ atom) within the catalytic triad (Ser200, His440, and Glu327) (ACh/TcAChE structure 2ace). The residues Trp84 and Phe330 are also important in the ligand recognition .
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Joel L. Sussman, Alexander Berchansky, Ralf Stephan, Harry Greenblatt, David Canner