Acetylcholine

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Acetylcholine at the Wikipedia

Acetylcholine

Computed model of acetylcholine

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Acetylcholinesterase hydrolysizes the neurotransmitter acetylcholine (ACh), producing choline and an acetate group. ACh directly binds Ser200 (via its nucleophilic Oγ atom) within the catalytic triad (Ser200, His440, and Glu327) of Torpedo californica acetylcholinesterase (TcAChE structure 2ace). The residues Trp84 and Phe330 are also important in the ligand recognition.