Sandbox 179

Pepsin

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Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. Andrea Gorrell.

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D load='5pep' size='350' frame='false' scene='Sandbox_179/Scenedefault/2'
5pep, resolution 2.34Å (default scene)
Activity:	Pepsin A, with EC number 3.4.23.1
Structural annotation: Resources: CATH : 5Pepa01, 5Pepa02 InterPro : Ipr001461, Ipr001969, Ipr021109, Ipr012848, Ipr009007 Pfam : PF00026 SCOP : d5pepa_
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

Protein Function

Pepsin is one of three proteolytic, or protein degrading enzymes in the digestive system. It resides in the alimentary canal and is produced by mucosal cells <ref>. Pepsin degrades peptides, and is optimally active at low pHs <ref>. Pepsin is an aspartic proteinase, more specifically a eukaryotic aspartic protease enzyme (3). Aspartic proteinases are widespread in nature, and pepsin in particular has been known to be medically important (2).

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Overall Structure

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