Calcium-free Calmodulin

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Calcium-free Calmodulin

General Information

Calmodulin is a molecule that has been studied extensively in its functions within the cell, and has an important role in relaying Ca2+ signals within the cytosol. ^[1] It does this by binding to Ca2+, undergoing a conformational change, and may interact with various proteins within the cell.^[2]^[3]^[4] Once bound to a target protein, it undergoes a further conformational change and may activate certain systems. For example, there is a Ca2+ pump in the plasma membrane pump that is activated by the binding of Ca2+-bound calmodulin, and then uses ATP to drive the Ca2+ out of the cell. ^[5]

Calcium-bound Calmodulin

The structure of calcium-bound calmodulin had previously been discovered using x-ray crystallography ^[6]

File:1cfc.png

1cfc, 25 NMR models (default scene)

Related:

1cfd

Structural annotation:
Resources:	CATH : 1Cfc000 InterPro : Ipr001125, Ipr002048, Ipr011992 Pfam : PF00036 SCOP : d1cfc__ UniProt : P62155

Functional annotation:
Molecular function:	protein binding calcium ion binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

TextToBeDisplayed

References

↑ Hoeflich, K.P., & Ikura, M.. Calmodulin in action: diversity in target recognition and activation mechanisms, Cell. 2002 108:739-742
↑ Cite error: Invalid <ref> tag; no text was provided for refs named ”5CRT”
↑ Kuboniwa H, Tjandra N, Grzesiek S, Ren H, Klee CB, Bax A. Solution structure of calcium-free calmodulin. Nat Struct Biol. 1995 Sep;2(9):768-76. PMID:7552748
↑ Babu YS, Bugg CE, Cook WJ. Structure of calmodulin refined at 2.2 A resolution. J Mol Biol. 1988 Nov 5;204(1):191-204. PMID:3145979
↑ Berridge MJ, Bootman MD, Roderick HJ. Calcium signalling: dynamics, homeostasis and remodelling. Nature Reviews. Molecular Cell Biology, 2003 4(7), pp. 517-29; PMID: 12838335
↑ Cite error: Invalid <ref> tag; no text was provided for refs named ”1CRT”

Babu YS, Bugg CE, Cook WJ. Structure of calmodulin refined at 2.2 A resolution. J Mol Biol. 1988 Nov 5;204(1):191-204. PMID:3145979

Kuboniwa H, Tjandra N, Grzesiek S, Ren H, Klee CB, Bax A. Solution structure of calcium-free calmodulin. Nat Struct Biol. 1995 Sep;2(9):768-76. PMID:7552748

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Christopher Truscott, Andrea Gorrell, Michal Harel, Alexander Berchansky, David Canner

[1CRT-1] Hoeflich, K.P., & Ikura, M.. Calmodulin in action: diversity in target recognition and activation mechanisms, Cell. 2002 108:739-742

[”5CRT”-2] Cite error: Invalid <ref> tag; no text was provided for refs named ”5CRT”

[4CRT-3] Kuboniwa H, Tjandra N, Grzesiek S, Ren H, Klee CB, Bax A. Solution structure of calcium-free calmodulin. Nat Struct Biol. 1995 Sep;2(9):768-76. PMID:7552748

[3CRT-4] Babu YS, Bugg CE, Cook WJ. Structure of calmodulin refined at 2.2 A resolution. J Mol Biol. 1988 Nov 5;204(1):191-204. PMID:3145979

[6CRT-5] Berridge MJ, Bootman MD, Roderick HJ. Calcium signalling: dynamics, homeostasis and remodelling. Nature Reviews. Molecular Cell Biology, 2003 4(7), pp. 517-29; PMID: 12838335

[”1CRT”-6] Cite error: Invalid <ref> tag; no text was provided for refs named ”1CRT”

[7] Babu YS, Bugg CE, Cook WJ. Structure of calmodulin refined at 2.2 A resolution. J Mol Biol. 1988 Nov 5;204(1):191-204. PMID:3145979

[8] Kuboniwa H, Tjandra N, Grzesiek S, Ren H, Klee CB, Bax A. Solution structure of calcium-free calmodulin. Nat Struct Biol. 1995 Sep;2(9):768-76. PMID:7552748

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Calcium-free Calmodulin

Contents