3ho5 | pdb_00003ho5
From Proteopedia
Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex
Disease
Known disease associated with this structure: Coloboma, ocular OMIM:[600725], Holoprosencephaly-3 OMIM:[600725], Microphthalmia, isolated, with coloboma 5 OMIM:[600725], Solitary median maxillary central incisor OMIM:[600725]
About this Structure
3HO5 is a 3 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Bosanac I, Maun HR, Scales SJ, Wen X, Lingel A, Bazan JF, de Sauvage FJ, Hymowitz SG, Lazarus RA. The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling. Nat Struct Mol Biol. 2009 Jul;16(7):691-7. Epub 2009 Jun 28. PMID:19561609 doi:10.1038/nsmb.1632
Page seeded by OCA on Wed Apr 28 10:48:23 2010
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Bosanac, I.
- Hymowitz, S G.
- Alternative splicing
- Autocatalytic cleavage
- Calcium cation
- Cell membrane
- Cytoplasm
- Developmental protein
- Disease mutation
- Disulfide bond
- Egf domain
- Egf-like domain
- Glycoprotein
- Holoprosencephaly
- Hydrolase
- Lipoprotein
- Membrane
- Microphthalmia
- Palmitate
- Polymorphism
- Protease
- Receptor ectodomain
- Secreted
- Signaling protein
- Six-bladed-propeller domain
- Zinc cation
