User:Daniel Seeman/DELETE

spinqualitylabelsall models Toggle between active site inhibitor bound and allosterically inhibited caspase-7 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

Forms of Caspase-7

• Caspase-7 bound to dead-end substrate mimic DEVD-CHO, trapping protein in active/substrate bound conformation.
• Caspase-7 bound to allosteric inhibitor DICA through CYS290 trapping protein in a form incompatible with substrate binding.
• Conformational change between substrate bound and substrate incompatible forms of Caspase-7.

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Molecular Playground banner: Conformational Dynamics between active and allosterically inhibited caspase-7 elucidate the mechanism of allostery in this important class of cysteine proteases.

Proteopedia Page Contributors and Editors (what is this?)

Daniel Seeman, Jaime Prilusky