104d | pdb_0000104d
DNA DUPLEXES FLANKED BY HYBRID DUPLEXES: THE SOLUTION STRUCTURE OF CHIMERIC JUNCTIONS IN
|
Overview
Hybrid duplexes and chimeric duplexes containing hybrid segments linked to, pure DNA (or pure RNA) segments are involved in transcription and, replication, as well as reverse transcription. A complete understanding of, the mechanism of these processes requires detailed information on such, duplexes and the junctions between duplexes of differing structure. Using, two-dimensional NMR, restrained molecular dynamics and mechanics, and, back-calculation refinement against the nuclear Overhauser effect spectra, at various mixing times, we have determined the solution structure of the, chimeric duplex [r(cgcg)d-(TATACGCG)]2 containing a pure DNA segment in, the center of a hybrid duplex. The solution structure differs from the, previously determined X-ray structure of the analogous duplex, ... [(full description)]
About this Structure
104D is a [Protein complex] structure of sequences from [[1]]. Full crystallographic information is available from [OCA].
Reference
DNA duplexes flanked by hybrid duplexes: the solution structure of chimeric junctions in [r(cgcg)d(TATACGCG)]2., Zhu L, Salazar M, Reid BR, Biochemistry. 1995 Feb 21;34(7):2372-80. PMID:7857947
Page seeded by OCA on Mon Oct 29 15:38:05 2007
