3l8v | pdb_00003l8v
From Proteopedia
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a biarylamine based inhibitor
Template:ABSTRACT PUBMED 20382527
Disease
Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[164860], Renal cell carcinoma, papillary, familial and sporadic OMIM:[164860], Autism, suseptibility to, 9 OMIM:[164860]
About this Structure
3L8V is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Williams DK, Chen XT, Tarby C, Kaltenbach R, Cai ZW, Tokarski JS, An Y, Sack JS, Wautlet B, Gullo-Brown J, Henley BJ, Jeyaseelan R, Kellar K, Manne V, Trainor GL, Lombardo LJ, Fargnoli J, Borzilleri RM. Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors. Bioorg Med Chem Lett. 2010 May 1;20(9):2998-3002. Epub 2010 Jan 20. PMID:20382527 doi:10.1016/j.bmcl.2010.01.042
Page seeded by OCA on Wed May 5 11:58:17 2010
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Receptor protein-tyrosine kinase
- Sack, J.
- Alternative splicing
- Atp-binding
- Chromosomal rearrangement
- Disease mutation
- Disulfide bond
- Glycoprotein
- Grb2
- Kinase
- Membrane
- Nucleotide-binding
- Phosphoprotein
- Polymorphism
- Proto-oncogene
- Receptor
- Receptor tyrosine kinase
- Shc
- Signal transduction
- Transferase
- Transmembrane
- Tyrosine-protein kinase
