3kfd | pdb_00003kfd

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File:3kfd.png

Template:STRUCTURE 3kfd

Ternary complex of TGF-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily

Template:ABSTRACT PUBMED 20207738

Disease

Known disease associated with this structure: Colorectal cancer, hereditary nonpolyposis, type 6 OMIM:[190182], Esophageal cancer OMIM:[190182], Loeys-Dietz syndrome, type 1B OMIM:[190182], Loeys-Dietz syndrome, type 2B OMIM:[190182], Loeys-Dietz syndrome, type 1A OMIM:[190181], Loeys-Dietz syndrome, type 2A OMIM:[190181]

About this Structure

3KFD is a 12 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Radaev S, Zou Z, Huang T, Lafer EM, Hinck AP, Sun PD. Ternary complex of transforming growth factor-beta1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily. J Biol Chem. 2010 May 7;285(19):14806-14. Epub 2010 Mar 5. PMID:20207738 doi:10.1074/jbc.M109.079921

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