3knb | pdb_00003knb

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Template:STRUCTURE 3knb

File:3knb.png

Crystal structure of the titin C-terminus in complex with obscurin-like 1

Template:ABSTRACT PUBMED 20489725

Disease

Known disease associated with this structure: Cardiomyopathy, dilated, 1G OMIM:[188840], Cardiomyopathy, familial hypertrophic OMIM:[188840], Muscular dystrophy, limb-girdle, type 2J OMIM:[188840], Myopathy, early-onset, with fatal cardiomyopathy OMIM:[188840], Myopathy, proximal, with early respiratory muscle involvement OMIM:[188840], Tibial muscular dystrophy, tardive OMIM:[188840]

About this Structure

3KNB is a 2 chains structure with sequences from Homo sapiens. This structure supersedes the now removed PDB entry 3irg. Full crystallographic information is available from OCA.

Reference

  1. Sauer F, Vahokoski J, Song YH, Wilmanns M. Molecular basis of the head-to-tail assembly of giant muscle proteins obscurin-like 1 and titin. EMBO Rep. 2010 Jul;11(7):534-40. Epub 2010 May 21. PMID:20489725 doi:10.1038/embor.2010.65

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