Sandbox 167

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2d1s, resolution 1.30Å (default scene)
Ligands: CL, SLU
Non-Standard Residues: CSO
Activity: Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing), with EC number 1.13.12.7
Related: 2d1r, 2d1t
Resources: FirstGlance, OCA, PDBsum, RCSB, TOPSAN
Coordinates: save as pdb, mmCIF, xml




Introduction

Japanese firefly. [1]

Structure

Structure of japanese firefly luciferase.[1]. The β-barrel structure actually has some homology with the human muscle fatty acid binding protein (m-FABP, pdb= 1HMT).

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Figure 1: Caption for figure 1
Notes about the image

Second image

Notes about the image

Luciferase Reaction

Typically, luciferases produce light through a high energy complex with a luciferin cofactor, and Mg-ATP.




Related Links

Pymol molecular viewer

Protein Data Bank file on 1VPR

NCBI protein entry on P. lunula luciferase

References

  1. ↑ 1.0 1.1 Schultz LW, Liu L, Cegielski M, Hastings JW. Crystal structure of a pH-regulated luciferase catalyzing the bioluminescent oxidation of an open tetrapyrrole. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1378-83. Epub 2005 Jan 21. PMID:15665092