Tropomyosin

Tropomyosin (TPM) has a 4-helix coiled dimer structure. It regulates the binding of myosin thus regulating muscle contraction. In its locked conformation it binds troponin T (TnnT) and prevents the binding of myosin to actin. When Ca++ ions bind to TnnT, the TPM assumes an open conformation and myosin can bind to actin. You can enlarge the image at the right for clarity.

File:1c1g.png

Crystal Structure of Pig Tropomyosin, 1c1g

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D load='1c1g' size='300' frame='false' scene='Tropomyosin/Cv/1'
Tropomyosin from pig, 1c1g
Structural annotation: Resources: InterPro : Ipr000533 Pfam : PF00261 SCOP : d1c1ga_, d1c1gb_, d1c1gc_, d1c1gd_ UniProt : P42639
Functional annotation: Cellular component: cytoskeleton cytoplasm Molecular function: actin binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

3D Structures of Tropomyosin

3mtu, 3mud – cTPM alpha-1 – chicken
1ic2 - cTPM alpha-1 (mutant)
2w49 – cTnnC+cTnnT+cTnnI+cTPM alpha-1+cActin
2z5h – yTPM alpha-1 N-terminal+C-terminal+GNC4 leucine zipper+TnnT – yeast
2z5i - yTPM alpha-1 N-terminal+C-terminal+GNC4 leucine zipper
2efr, 2efs, 2d3e - rTPM alpha-1 C-terminal+GNC4 leucine zipper – rabbit
1kql - TPM alpha-1 C-terminal+GNC4 leucine zipper - rat
2b9c – TPM mid region – rat
1c1g – TPM – pig
2tma – TPM - model

Proteopedia Page Contributors and Editors (what is this?)

Gregory Hoeprich, Alexander Berchansky, David Canner, Joel L. Sussman, Jaime Prilusky, Michal Harel