Fibrinogen
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Fibrinogen is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, thrombin, exposing Knobs A & B to form fibrin. It is this fibrin that is linked to clotting factors like factor XIII which form clots to prevent excessive bleeding from wounds sustained.
3D Structure of Fibrinogen
Fibrinogen is composed of 3 non-identical chains alpha, beta, gamma (Fba, Fbb, Fbg) .
Fibrinogen alpha+beta+gamma chains
3hus, 3h32, 3e1i, 3bvh, 2hlo, 2hod, 2hpc, 2oyh, 2oyi, 2h43, 2ffd, 1re3, 1rf1, 1n86, 1ltj – hFba+hFbb+hFbg+peptide ligand – human
3ghg, 2q9i, 2z4e - hFba+hFbb+hFbg+knob A & B
2a45 - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor
1re4, 1rf0, 1n8e, 1lt9 - hFba+hFbb+hFbg
1jy3, 1deq – cFba+cFbb+cFbg - cow
1n73, 1lwu - Fba+Fbb+Fbg+peptide ligand – Sea lamprey
1m1j - heFba+heFbb+heFbg+peptide ligand – hen
1ei3 - heFba+heFbb+heFbg
Fibrinogen alpha chain
1fzd – hFba EC domain
2jor – cFba – NMR
2baf – cFba
Fibrinogen beta chain
1fzf, 1fzg – hFb fragment double-D +peptide ligand
1fze, 1fza, 1fzb – hFb fragment D
Fibrinogen gamma chain
2vr3 – hFbg+SaClumping Factor A – Staphylococcus aureus
2vdo, 2vdp, 2vdq, 2vdr – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains
2fib, 3fib - hFbg+peptide ligand
1fib – hFbg+Ca
1fic, 1fid - hFbg
Proteopedia Page Contributors and Editors (what is this?)
David Canner, Mark Hoelzer, Michal Harel, Alexander Berchansky, Angel Herraez, Marius Mihasan
