1anr | pdb_00001anr
CIS-ACTING RNA REGULATORY ELEMENT (HIV-1 TAR), NMR, 20 STRUCTURES
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Overview
Efficient transcription from the human immunodeficiency virus (HIV), promoter depends on binding of the viral regulatory protein Tat to a, cis-acting RNA regulatory element, TAR. Tat binds at a trinucleotide bulge, located near the apex of the TAR stem-loop structure. An essential feature, of Tat-TAR interaction is that the protein induces a conformational change, in TAR that repositions the functional groups on the bases and the, phosphate backbone that are critical for specific intermolecular, recognition of TAR RNA. We have previously determined a high resolution, structure for the bound form of TAR RNA using heteronuclear NMR. Here, we, describe a high resolution structure of the free TAR RNA based on 871, experimentally determined restraints. In the free TAR RNA, bulged residues, U23 ... [(full description)]
About this Structure
1ANR is a [Protein complex] structure of sequences from [[1]]. Structure known Active Site: TAR. Full crystallographic information is available from [OCA].
Reference
Structure of HIV-1 TAR RNA in the absence of ligands reveals a novel conformation of the trinucleotide bulge., Aboul-ela F, Karn J, Varani G, Nucleic Acids Res. 1996 Oct 15;24(20):3974-81. PMID:8918800
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