B-RAF with PLX4032

B-RAF with PLX4032

PLX4032 is a newly synthesized drug that is being used to treat malignant melanonma with a specific mutation. The mutation is B-RAF^(V600E). This drug is highly selective for this mutation and will not bind to wild type B-RAF.

PLX 4032
V600E mutation
TextToBeDisplayed DFG in
DFG out

spinqualitylabelsall models testcaption Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

spinqualitylabelsall models testcaption Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

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Jens Hemmingsen, J.D. Woodruff, Michal Harel