B-RAF with PLX4032

B-RAF with PLX4032

PLX4032 is a newly synthesized drug that is being used to treat malignant melanoma with a specific mutation. The mutation is B-RAF^(V600E). This drug is highly selective for this mutation and will not bind to wild type B-RAF.

PLX 4032
ATP
Wild-Type B-RAF
V600E Mutation
PLX4032 Sulfonamide N
H-Bond Interaction Asp594 and PLX4032
DFG in
DFG out
Superposition
Confirmation Change DFG-In
Confirmation Change DFG-Out

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Jens Hemmingsen, J.D. Woodruff, Michal Harel