Pioglitazone

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Better Known as: Actos

• Marketed By: Takeda Pharmaceuticals
  
• Major Indication: Hypoglycemia & Type 2 Diabetes
  
• Drug Class: PPAR-γ Activator - Thiazolidinedione (Glitazones)
• Date of FDA Approval (Patent Expiration): 1999 (2011)
  
• 2009 Sales: $2.4 Billion
• Why You Should Care: It is the best selling drug to treat Diabetes and is the 10th best selling drug in the United States.
• The following is a list of Pharmacokinetic Parameters. See: Pharmaceutical Drugs for more information

Pharmacokinetics

Glitazone Comparison
Parameter	Pioglitazone (Actos)	Rosiglitazone (Avandia)
Tmax (hr)
Cmax (ng/ml)
Bioavailability (%)
Protein Binding (%)	99	99
T1/2 (hr)	3-7	3-4
AUC (ng/ml/hr)
IC50 (nM)
Equivalent Dosage (mg)
Metabolism	Hepatic (CYP2C8)	Hepatic (CYP2C8)

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