Leucine-rich repeat

A large family of over 60,000 horseshoe- or arc-shaped proteins named for a repeated motif that always contains leucine.

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D load='3e6j' size='400' frame='false' scene='Lamprey_Variable_Lymphocyte_Receptor/Defaultjmol/1'
Lamprey Variable Lymphocyte Receptor (3e6j), resolution 1.67Å (initial scene)
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

Articles in Proteopedia concerning Leucine-rich repeat proteins include:

• • Human Follicle Stimulating Hormone Complexed with its Receptor
  • Variable Lymphocyte Receptor
  • Lamprey Variable Lymphocyte Receptor

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D load='1xwd' size='350' frame='false' scene=
1xwd, resolution 2.92Å (default scene)
Ligands:	BMA, NAG, SO4
Gene:	CGA (Homo sapiens), FSHB (Homo sapiens), FSHR (Homo sapiens)
Structural annotation: Resources: CATH : 1Xwda00, 1Xwdb00, 1Xwdd00, 1Xwde00 InterPro : Ipr000476, Ipr002400, Ipr006208, Ipr001545, Ipr000276, Ipr001611, Ipr002131, Ipr002272, Ipr000372 Pfam : PF00236, PF00007, PF01462, PF00560 UniProt : P01215, P01225, P23945
Functional annotation: Cellular component: extracellular region soluble fraction membrane plasma membrane integral to membrane Biological process: signal transduction cell-cell signaling spermatogenesis Sertoli cell proliferation female gamete generation ovarian follicle development female pregnancy gonad development G-protein coupled receptor protein signaling pathway female gonad development Molecular function: hormone activity follicle-stimulating hormone activity protein heterodimerization activity signal transducer activity protein binding follicle-stimulating hormone receptor activity G-protein coupled receptor activity protein-hormone receptor activity receptor activity rhodopsin-like receptor activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

To view automatically seeded indices concerning Leucine-rich repeat proteins, see:

• • Leucine-rich repeat
  • Leucine-rich-repeat
  • Leucine-rich repeat-containing protein 4
  • LRR
  • Category:Leucine-rich repeat glycoprotein

See Also

• Toll-like receptors (TLRs)

Additional Literature

<references group="xtra"/

Proteopedia Page Contributors and Editors (what is this?)

Wayne Decatur, Jaime Prilusky, Michal Harel