Leucine-rich repeat

A large family of over 60,000 horseshoe- or arc-shaped proteins named for a repeated motif that always contains leucine.^[1]

Lamprey Variable Lymphocyte Receptor (3e6j), resolution 1.67Å (initial scene)

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

Articles in Proteopedia concerning Leucine-rich repeat proteins include:

Ligands:

BMA, NAG, SO4

Gene:

CGA (Homo sapiens), FSHB (Homo sapiens), FSHR (Homo sapiens)

Structural annotation:
Resources:	CATH : 1Xwda00, 1Xwdb00, 1Xwdd00, 1Xwde00 InterPro : Ipr000476, Ipr002400, Ipr006208, Ipr001545, Ipr000276, Ipr001611, Ipr002131, Ipr002272, Ipr000372 Pfam : PF00236, PF00007, PF01462, PF00560 UniProt : P01215, P01225, P23945

Functional annotation:
Cellular component:	extracellular region soluble fraction membrane plasma membrane integral to membrane
Biological process:	signal transduction cell-cell signaling spermatogenesis Sertoli cell proliferation female gamete generation ovarian follicle development female pregnancy gonad development G-protein coupled receptor protein signaling pathway female gonad development
Molecular function:	hormone activity follicle-stimulating hormone activity protein heterodimerization activity signal transducer activity protein binding follicle-stimulating hormone receptor activity G-protein coupled receptor activity protein-hormone receptor activity receptor activity rhodopsin-like receptor activity

Evolutionary conservation:

Toggle Conservation Colors:

Rows = identical sequences:

Further Information:

Caveats,

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

To view automatically seeded indices concerning Leucine-rich repeat proteins, see:

References

↑ Matsushima N, Miyashita H, Mikami T, Kuroki Y. A nested leucine rich repeat (LRR) domain: the precursor of LRRs is a ten or eleven residue motif. BMC Microbiol. 2010 Sep 9;10:235. PMID:20825685 doi:10.1186/1471-2180-10-235

Kobe B, Kajava AV. The leucine-rich repeat as a protein recognition motif. Curr Opin Struct Biol. 2001 Dec;11(6):725-32. PMID:11751054
Kim HM, Oh SC, Lim KJ, Kasamatsu J, Heo JY, Park BS, Lee H, Yoo OJ, Kasahara M, Lee JO. Structural diversity of the hagfish variable lymphocyte receptors. J Biol Chem. 2007 Mar 2;282(9):6726-32. Epub 2006 Dec 27. PMID:17192264 doi:10.1074/jbc.M608471200
Matsushima N, Tanaka T, Enkhbayar P, Mikami T, Taga M, Yamada K, Kuroki Y. Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors. BMC Genomics. 2007 May 21;8:124. PMID:17517123 doi:10.1186/1471-2164-8-124
Matsushima N, Tachi N, Kuroki Y, Enkhbayar P, Osaki M, Kamiya M, Kretsinger RH. Structural analysis of leucine-rich-repeat variants in proteins associated with human diseases. Cell Mol Life Sci. 2005 Dec;62(23):2771-91. PMID:16231091 doi:10.1007/s00018-005-5187-z
Kajava AV, Kobe B. Assessment of the ability to model proteins with leucine-rich repeats in light of the latest structural information. Protein Sci. 2002 May;11(5):1082-90. PMID:11967365 doi:10.1110/ps.4010102