3b8z | pdb_00003b8z
High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)
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Overview
Aggrecanase-2 [a disintegrin and metalloproteinase with thrombospondin, motifs-5 (ADAMTS-5)], a member of the ADAMTS protein family, is critically, involved in arthritic diseases because of its direct role in cleaving the, cartilage component aggrecan. The catalytic domain of aggrecanase-2 has, been refolded, purified, crystallized and its 3-dimensional structure, determined to 1.4A resolution in the presence of an inhibitor. A high, resolution structure of an ADAMTS/aggrecanase protein provides an, opportunity for the development of therapeutics to treat osteoarthritis.
About this Structure
3B8Z is a Single protein structure of sequence from Homo sapiens with ZN, CA and 294 as ligands. Full crystallographic information is available from OCA.
Reference
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)., Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A, J Biol Chem. 2007 Nov 8;. PMID:17991750
Page seeded by OCA on Wed Jan 23 11:47:54 2008
