Cytochrome P450
Cytochrome P450 (CYP) catalyzes the oxidation of organic substances like lipids. The CYP contains a heme cofactor. The protein is numbered by its gene. CYP-cam catalyzes the hydroxylation of camphor. P450nor is a Nitric Oxide Reductase CYP. The images at the left and at the right correspond to one representative CYP, i.e. the crystal structure of human CYP2 (2f9q).
3D Structures of Cytochrome P450
CYP/P450 reductase
3kx3, 3kx4, 3kx5, 3hf2, 3dgi, 3cbd, 2nnb, 1zo4, 2yqo, 2yqp, 1smi, 1p0v, 1p0w, 1p0x, 1jme – BmCYP102A1/P450 reductase (mutant) – Bacilus megaterium
1zo9 - BmCYP102A1/P450 reductase+N-palmitoylmethionine
1zoa, 1jpz - BmCYP102A1/P450 reductase (mutant)+N-palmitoylglycine
1smj - BmCYP102A1/P450 reductase (mutant)+N-palmitoleate
human CYP1 family
2hi4 – hCYP1A2+naphthoflavone - human
human CYP2 family
3gph, 3koh, 3lc4 – hCYP2E1 fragment +imidazole derivative
3e6i – hCYP2E1 fragment+indazole
3ebs – hCYP2A6 (mutant)+phenacetin
2fdu, 2fdv, 2fdw, 2fdy - hCYP2A6+pyridine derivative
3e4e – hCYP2E1 fragment+methylpyrazole
3czh, 3dl9, 3c6g – hCYP2R1+vitamin D
2nnh – hCYP2C8+retinoic acid
2nni - hCYP2C8+montelukast
2nnj - hCYP2C8+felodipine
1pq2 - hCYP2C8
1og2, 1og5 – hCYP2C9 (mutant)
1r9o – hCYP2C9 (mutant)+flurbiprofen
2pg5, 2pg6, 2pg7 – hCYP2A6 (mutant)
2p85 – hCYP2A13 (mutant)+indole
3ibd – hCYP2B6 (mutant)+4-(4-chlorophenyl)imidazole
2f9q – hCYP2D6
2z10 – hCYP2A6+coumarin
1z11 - hCYP2A6+methoxalen
human CYP3 family
2v0m – hCYP3A4+ketoconazole
2j0d - hCYP3A4+erythromycin
1tqn, 1w0e, 1w0f, 1w0g – hCYP3A4
human CYP7 family
3dax – hCYP7A1
human CYP19 family
3eqm - hCYP19A1+androstenedione
human CYP46 family
2q9f – hCYP46A1+cholesterol
2q9d - hCYP46A1
2vn0 – hCYP105A1+troglitazone
2zby - hCYP105A1 (mutant)
CYP from Mycobacterium tuberculosis
2vku, 1h5z – MtCYP51 - Mycobacterium tuberculosis
2ci0, 2cib, 1u13 - MtCYP51 (mutant)
1x8v - MtCYP51 (mutant)+estriol
1ea1 - MtCYP51 (mutant)+ fluconazole
1e9x - MtCYP51 (mutant)+ phenylimidazole
3cxv, 3cxx, 3cxy, 3cxz, 3cy0, 3cy1 - MtCYP121 (mutant)
3g5f, 3g5h, 2ij5, 1n40 – MtCYP121
2ij7 - MtCYP121+fluconazole
1n4g - MtCYP121+iodopyrazole
3ivi, 3iw0 – MtCYP125
3iw1 - MtCYP125+androstenedione
3iw2 - MtCYP125+econazole
2uvn - MtCYP130+econazole
2wgy – MtCYP130 (mutant)
2w09, 2w0b, 2w0a - MtCYP130 (mutant)+pyridine inhibitor
2uuq – MtCYP130
CYP-cam
2qbl, 2qbm, 2qbn, 2gqx, 2gr6, 2frz, 2h7s, 6cp4, 2cp4, 3cp4, 4cp4 – PpCYP-cam (mutant) – Pseudomona putida 1dz4, 1dz8, 1dz6, 1dz9, 5cp4, 1phc, 2cpp - PpCYP-cam 2qbo - PpCYP-cam (mutant)+cyanide 1qmq - PpCYP-cam (mutant)+Ru substrate 2h7q - PpCYP-cam+imidazole 1cp4 - PpCYP-cam+benzene 1akd - PpCYP-cam+1S-camphor 2fe6, 2fer, 2feu - PpCYP-cam+Mn protoporphyrin IX 1uyu - PpCYP-cam + Xe 1076 - PpCYP-cam +cyanide 4cpp - PpCYP-cam+adamantine 5cpp - PpCYP-cam+adamantanone 6cpp - PpCYP-cam+camphene 7cpp - PpCYP-cam+norcamphor 8cpp- PpCYP-cam+thiocamphor 3cpp - PpCYP-cam+CO 1pha, 1phb, 1phd, 1phe, 1phf, 1phg - PpCYP-cam+imidazole derivative 1gek, 1gem - PpCYP-cam +N-butyl-isocyanide 1lwl - PpCYP-cam +fluorescent probe 2h7r - PpCYP-cam (mutant)+imidazole 1k2o - PpCYP-cam (mutant)+pyridine derivative 1gjm - PpCYP-cam (mutant)+sulphydryl reagent 2a1m, 2a1n, 2a10 - PpCYP-cam (mutant)+ferrous dioxygen 1t85, 1t86, 1t87, 1t88 - PpCYP-cam (mutant)+ferrous CO
P450nor
1cl6, 1rom – FoP450nor - Fusarium oxysporum 2rom - FoP450nor+CO 1cmj, 1cmn - FoP450nor (mutant) 1xqd – FoP450nor+pyridinealdehyde adenine 1jfb, 1jfc, 1ged - FoP450nor 1gej, 1gei - FoP450nor+N-butyl-isocyanide 1ulw - FoP450nor (mutant)
rabbit CYP
2bdm – rCYP2B4 – rabbit 1po5 - rCYP2B4 (mutant) 1suo - rCYP2B4 (mutant)+imidazole 1dt6 - rCYP2C5 (mutant) 1nr6 – rCYP2C5+diclofenac 1n6b - rCYP2C5+sulfaphenazole
Other CYPs
1ued – AoCYP oxyC – Amycolatopsis orientalis 1lfk, 1lg9, 1lgf - AoCYP oxyB 1q5d – ScCYPEPOK+epothilone – Sorangium cellulosum 1q5e - ScCYPEPOK 1io8 – SsCYP119 (mutant) – Sulfolobus solfataricus 1io9, 1io7, 1f4u - SsCYP119 1f4t - SsCYP119+ phenylimidazole 1cpt – CYP108 – Pseudomonas sp. 2uwh - BmCYP102+palmitic acid 3ekb, 3ekd, 3ekf, 2ij3, 2ij4 - BmCYP102 heme domain (mutant) 2ij2, 2hpd - BmCYP102 heme domain 3ben - BmCYP102 + imidazole derivative 2j1m, 2j4s - BmCYP102+DMSO 1bvy, 1bu7– BmCYP102A1 FMN domain 1fag – BmCYP102A1+ palmitic acid 1fah – BmCYP102A1 (mutant) 2bmh - BmCYP102A1 3aba – SaCYP105P1+filipin I – Streptomyces avermitilis 3abb – SaCYP105D6 3e5j, 3e5l - SaCYP105P1 (mutant) 3e5k - SaCYP105P1 (mutant)+4-phenylimidazole 2whw, 2wi9, 2vz7 – SvCYP107L1 (mutant) – Streptomyces venezuelae 2vzm – SvCYP107L1 (mutant)+narbomycin 2c7x - SvCYP107L1+narbomycin 2cd8, 2ca0, 2c6h – SvCYP107L1+YC-17 2bvj - SvCYP107L1 2zqj – BsCYP152A1 – Bacillus subtilis 2zqx - BsCYP152A1+heptanoic acid 1izo – BsCYP BS beta+ palmitoleic acid 1jin, 1jip - SeCYP107A1+ ketoconazole - Saccharopolyspora erythraea 1jio, 1oxa - SeCYP107A1+6DEB 1eup – SeCYP107A1+androstendione 1egy - SeCYP107A1+aminophenanthrene 2jjn, 2jjo - SeCYP113A1 (mutant) 2jjp - SeCYP113A1 (mutant)+ketoconazole 2vrv - SeCYP113A1 (mutant)+clotrimazole 3a1l – SsCYP245A1+dichlorochrompyrrolic acid – Streptomyces sp. 2z3t - SsCYP245A1 2z3u - SsCYP245A1+chromopyrrolic acid 3g5n, 3g93 – rCYP2B4 (mutant)+1-biphenyl-4-methyl-1H-imidazole – rabbit 2q6n – rCYP2B4 (mutant)+chlorophenyl-imidazole 3cv8 – SgCYP105A1 (mutant) – Streptomyces griseolus 3cv9, 2zbz - SgCYP105A1 (mutant)+vitamin D3 2zbx - SgCYP105A1+imidazole 3dam, 3dan, 3dbm– CYP74A2 – Parthenium argentatum 2rch, 3dsi – AtCYP74A+13(S)-HOD – Arabidopsis thaliana 3dsj - AtCYP74A (mutant)+13(S)-HOD 2rcl - AtCYP74A+vernolic acid 3dsk - AtCYP74A (mutant)+ vernolic acid 2rcm, 3cli - AtCYP74A 2rfb – PtCYP – Picrophilus torridus 2rfc – PtCYP+phenylimidazole 2nz5, 2nza, 2dkk – ScCYP158A1 – Streptomyces coelicolor 1gwi - ScCYP154C1 1wiy – TtCYP – Thermus thermophilus 1n97 – TtCYP175A1
